We drive from Cleveland to Tampa once a year.
I 71 through Ohio is daytime, but the rest of the trip happens overnight.
All using I 75:
KY TN GA FL
Arriving around breakfast.
Would a CB be of any benefit? When its 1am, in the hills of southern TN, is there much chatter about where the LEO might be waiting? The traffic is quite light in the 'deep' part of the night.